Migraine and depression: a shared genetic etiology?
Migraine and depression are both high prevalent disorders with a high burden of disease. They have a bidirectional comorbidity: patients with migraine have an increased risk of getting a depression, and vice versa. In some diseases, like hypercholesterolemia and myocardial infarction, a bidirectional comorbidity is caused by shared genetic factors. Our hypothesis is that migraine and depression are caused by shared genetic factors. In the present study we investigate the prevalence and migraine specific determinants of depression in a migraine population, whether migraine and depression are (at least partially) caused by shared genetic factors, the role of genetic factors in migraine chronification, the best therapy for patients with chronic migraine and medication overuse and which changes in brain structure and function are involved in the pathophysiology of (chronic) migraine.
Clinical-based, cross-sectional, observational studies in migraine populations and depressed population; Genome-Wide Association Study; A double blind, randomized, controlled trial in a population of chronic migraineurs with medication overuse, with and without comorbid depression.